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Objective To study the effect of intratympanic injection of triamcinolone acetonid on interleukin -4(IL-4) and interferon-gamma (IFN -γ) in patients with secretory otitis media.Methods 110 patients with secretory otitis media were selected , and they were randomly divided into the observation group and control group according to digital table ,55 cases in each group .All patients were treated with puncture in the tympanic cavity .The control group was injected with dexamethasone ,while the observation group was injected with triamcinolone acetonid . Two groups were treated for 2 times/week,continuous treatment for 1 month.Fasting blood samples were collected before and after treatment to determine serum IL -4 and IFN -γlevels.Results The total effective rate of the control group was 58.2％,which was significantly lower than 70.9％ of the observation group (χ2 =4.68,P <0.05).After treatment,the serum levels of IL-4 and IL-4/IFN-γin the two groups were significantly decreased (t=4.698,10.262,3.924,4.264,all P<0.01).After treatment,the serum IFN-γlevels were significantly higher in the two groups(t=3.016,5.116,all P<0.05).Compared with the control group after treatment ,the serum IL-4, IL-4/IFN-γin the observation group decreased more significantly (t=3.082,2.971,all P<0.01).The serum IFN-γlevel increased significantly (t =2.142,P <0.05).Conclusion Triamcinolone acetonid intratympanic injection can significantly improve the efficacy in patients with secretory otitis media , and improve the balance of Th1/Th2.
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[ABSTRACT]OBJECTIVETo study of the relationship of age and climate with the nasal mucosa lesions.METHODSAll the patients met with the inclusive criteria were registered and followed-up once a month and their nasal mucosal lesions were observed through nasal speculum and/or nasal endoscope. The recording data was analyzed by SPSS17.0 software.RESULTSA total of 259 patients, 555 person-times and 957 lesion spots were observed. The nasal mucosa was injured by airflow with the highest incidence rate from October to next year April. Patients numbers gradually increased after August, and significantly increased at November, December (P<0.05). Children aged from 2 to 12 years old and the adults aged from 40 to 80 years old were susceptible population (P<0.05), the incidence rate had a negative relation with humidity (P<0.05). The susceptible spots of the lesion were ranked as follows: Little area, inferior turbinate, mucosa of the both side of the deviated nasal septum, inferior meatus, middle meatus, middle turbinate and olfactory area. CONCLUSIONNasal mucosal injury relates to age and seasons. The nasal cavity airflow may be a factor of these lesions.
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OBJECTIVE@#To explore the organ damage character and complications of blunt trauma in the neck, and the advantage and disadvantage of CT and ultrasound for blunt trauma in the neck.@*METHOD@#The data of 7 neck blunt trauma cases was analyzed. Cricoarytenoid joint reduction, tracheotomy, exploratory surgery of neck were performed respectively for these cases.@*RESULT@#Of the 2 cases with vocal cord paralysis, one had his vocal cords fixed in the the para-median position. one had his vocal cords move freely. 2 cases of epiglottis edema had been cured. Among the 2 cases of thyroid area swelling and congestion, one died from respiratory failure, one was cured. One case died of carotid artery embolism.@*CONCLUSION@#Circulation of the head should be noticed as well as keeping respiratory tract clear and anti-shock treatment. Some patient with negative laryngeal examinations might get worse in the following hours, and swelling of the neck, dyspnea, obnubilation may appear in these cases. Dynamic monitoring could be helpful for the diagnosis and treatment of neck blunt trauma.